pathophysiological concepts in multiple sclerosis and the therapeutic effects of hydrogen sulfide

Authors

fatemeh talaei novel drug delivery systems lab, faculty of pharmacy, tehran university of medical sciences, tehran, iran.

abstract

introduction: multiple sclerosis (ms) is generally known as a manageable but not yet curable autoimmune disease affecting central nervous system. a potential therapeutic approach should possess several properties: prevent immune system from damaging the brain and spinal cord, promote differentiation of oligodendrocyte progenitor cells (opcs) into mature oligodendrocytes to produce myelin, prevent the formation of fibronectin aggregates by astrocytes to inhibit scar formation, and enhance function of healthy endothelial cells (ecs). methods: to determine if an increase in sulfur contents through h2s, a potent antioxidant known to induce protective autophagy in cells, could provide the above desired outcomes, peripheral blood mononuclear cells (pbmncs), ocps, astrocytes, and ecs were treated with nahs (50 μm) in vitro. results: transmigration assay using ec monolayer showed that serotonin increased migration of pbmnc while pretreatment of ec with nahs inhibited the migration induced by serotonin treatment. nahs upregulated proteins involved in immune system response and downregulated pbmncs- and ec-related adhesion molecules (lfa-1 and vcam-1). furthermore, it had a cell expansion inducing effect, altering ec morphology. the effects of nahs on opcs and astrocytes were studied compared to mtor inhibitor rapamycin. in nahs treated astrocytes the induced fibronectin production was partially inhibited while rapamycin almost fully inhibited fibronectin production. nahs slowed but did not inhibit the differentiation of ocps or the production of myelin compared to rapamycin. conclusion: the in vitro results point to the potential therapeutic application of hydrogen sulfide releasing molecules or health-promoting sulfur compounds in ms.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Pathophysiological Concepts in Multiple Sclerosis and the Therapeutic Effects of Hydrogen Sulfide

Introduction: Multiple sclerosis (MS) is generally known as a manageable but not yet curable autoimmune disease affecting central nervous system. A potential therapeutic approach should possess several properties: Prevent immune system from damaging the brain and spinal cord, promote differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes to p...

full text

Pathophysiological Concepts in Multiple Sclerosis and the Therapeutic Effects of Hydrogen Sulfide

INTRODUCTION Multiple sclerosis (MS) is generally known as a manageable but not yet curable autoimmune disease affecting central nervous system. A potential therapeutic approach should possess several properties: Prevent immune system from damaging the brain and spinal cord, promote differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes to produce myelin, preven...

full text

a study of the fifth child and ben in the world by doris lessing in the light of julia kristevas psychoanalytic concepts

این مطالعه به بررسی عوامل روانشناختی کریستوادردو رمان دوربس لسینگ،فرزندبنجم و بن دردنیای واقعی می بردازد.موفقیت یا شکست کاراکترهادر تکمیل شکست تتیزی یه کمک بدر وهم از مهم ترین دغدغه محقق می باشد.به بررسی تحلیل روانشناختی تمامی کاراکترها خصوصا بن برداخته و به دنبال نشانه هایی از جامعه شیشه ای کریستوا می باشد.

15 صفحه اول

O9: Mechanisms and Therapeutic Options in Multiple Sclerosis

Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system associated to myelin loss and neurodegeneration. Clinically patients suffer from diverse symptoms and face the risk to become wheelchair-bound. At the moment MS is incurable, thus there is an unmet need for therapeutic options.

full text

Therapeutic Applications of Monoclonal Antibodies in Multiple Sclerosis

Despite the various therapies available, the use of monoclonal antibodies is a highly specific approach that has only recently been of interest to researchers. The properties of antibodies have led to their use in the treatment of various diseases, including cancer, Alzheimer's disease, diabetes and multiple sclerosis (MS). MS, a chronic inflammatory disease, occurs commonly in young adults. Th...

full text

on translation of politeness strategies in dialogues involving female characters in translations and retranslations of novels translated before and after the islamic revolution of iran and their effects on the image of women: a polysystem theory approach

abstract reception environment has considerable effects on accepting a translation. as the expectations of a target culture and its values and needs change throughout history, its criteria for accepting a translation or rejecting it will change accordingly (gentzler, 2001). the expectations of iran, as the reception environment in the present study, have changed after the islamic revolution. i...

My Resources

Save resource for easier access later


Journal title:
basic and clinical neuroscience

جلد ۷، شماره ۲، صفحات ۱۲۱-۱۳۶

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023